Description

6-Chloro-2-(Trifluoromethyl)Nicotinaldehyde is a high-value, multi-functional chemical building block characterized by its reactive aldehyde group and halogenated pyridine core. This compound matters for its critical role in facilitating complex molecular transformations, enabling the synthesis of advanced intermediates for pharmaceuticals and agrochemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries seeking to introduce specific trifluoromethyl and chloro-substituted motifs into target molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and antiviral drug discovery programs.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing properties of the trifluoromethyl group.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Employed in the synthesis of functionalized organic molecules for electronic materials and liquid crystals.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.
• Academic and Industrial R&D: Used in research laboratories for methodological development and exploring new chemical spaces in heterocyclic chemistry.

Basic Information

Product Name	6-Chloro-2-(Trifluoromethyl)Nicotinaldehyde
CAS No.	1227581-44-3
Molecular Formula	C7H3ClF3NO
Molecular Weight	209.55 g/mol
Synonyms	6-Chloro-2-(trifluoromethyl)pyridine-3-carbaldehyde; 3-Pyridinecarboxaldehyde, 6-chloro-2-(trifluoromethyl)-; 6-Chloro-2-trifluoromethylnicotinaldehyde; 2-(Trifluoromethyl)-6-chloronicotinaldehyde; 6-Chloro-2-(trifluoromethyl)-3-pyridinecarboxaldehyde; 1227581-44-3; 6-Chloro-2-trifluoromethyl-3-pyridinecarbaldehyde
EINECS	Contact for details

Quality Control

Our 6-Chloro-2-(Trifluoromethyl)Nicotinaldehyde is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment, ensuring full traceability and compliance with your internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its sensitivity, the container should be kept under an inert atmosphere (e.g., nitrogen) to prevent oxidation and moisture ingress. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.