Description

Methyl 2-Bromo-3-Methylisonicotinate CAS NO 1227580-45-1 is a high-purity, functionalized pyridine derivative serving as a critical building block in advanced organic synthesis. This compound is valued for its reactive bromine and ester functional groups, enabling precise molecular construction. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly in kinase inhibitor and central nervous system (CNS) active compound research.
• Agrochemical Synthesis: Used to construct complex heterocyclic scaffolds found in modern pesticides and herbicides.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Building block for the development of functional organic materials, such as liquid crystals and electronic chemicals.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions.
• Academic & Contract Research: Essential reagent for method development and exploratory chemistry in university and CRO (Contract Research Organization) laboratories.

Basic Information

Product Name	Methyl 2-Bromo-3-Methylisonicotinate
CAS No.	1227580-45-1
Molecular Formula	C8H8BrNO2
Molecular Weight	230.06 g/mol
Synonyms	2-Bromo-3-methylisonicotinic acid methyl ester; Methyl 2-bromo-3-methylpyridine-4-carboxylate; 4-Pyridinecarboxylic acid, 2-bromo-3-methyl-, methyl ester; 2-Bromo-3-methyl-4-(methoxycarbonyl)pyridine; 3-Methyl-2-bromoisonicotinic acid methyl ester
EINECS	Contact for details

Quality Control

Every batch of Methyl 2-Bromo-3-Methylisonicotinate is manufactured under strict quality management systems. We employ advanced analytical techniques including HPLC, GC-MS, and NMR to ensure identity, purity, and consistency. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible organic solvents. The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.