Description

3-Fluoro-4-Iodopyridin-2(1H)-One is a high-value halogenated pyridinone derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its unique structure, featuring both fluorine and iodine substituents, makes it a versatile building block for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by pharmaceutical and agrochemical R&D teams for the synthesis of novel active ingredients, including potential kinase inhibitors and other biologically relevant heterocycles.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those targeting kinase pathways and other enzyme families.
• Agrochemical Research: Used to develop novel active ingredients for crop protection products, leveraging its halogenated structure for bioactivity.
• Chemical Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Sonogashira) and nucleophilic substitution reactions to introduce the fluoropyridinone scaffold.
• Material Science Research: Serves as a monomer or functionalizing agent in the development of advanced organic electronic materials and ligands for catalysis.
• Academic & Contract Research: Utilized in university and CRO laboratories for methodological development and exploring new chemical spaces in heterocyclic chemistry.

Basic Information

Product Name	3-Fluoro-4-Iodopyridin-2(1H)-One
CAS No.	1227580-21-3
Molecular Formula	C5H3FINO
Molecular Weight	238.99 g/mol
Synonyms	3-Fluoro-4-iodo-1H-pyridin-2-one; 3-Fluoro-4-iodopyridin-2(1H)-one; 4-Iodo-3-fluoropyridin-2(1H)-one; 2(1H)-Pyridinone, 3-fluoro-4-iodo-; 3-Fluoro-4-iodo-2-hydroxypyridine; 3-Fluoro-4-iodo-2-pyridinol; 3-Fluoro-4-iodo-2(1H)-pyridone
EINECS	Contact for details

Quality Control

Our 3-Fluoro-4-Iodopyridin-2(1H)-One is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent moisture absorption and potential degradation. Recommended storage temperature is 2-8°C for extended stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.