Description

2,3-Difluoro-6-Methylpyridine is a high-purity fluorinated pyridine derivative, a key building block in advanced organic synthesis. Its value lies in its unique substitution pattern, which enables precise molecular modifications critical for developing novel compounds with targeted properties. This intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for creating active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for drugs targeting the central nervous system and anti-infectives.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the difluoro-methylpyridine moiety enhances biological activity and environmental profile.
• Ligand and Catalyst Development: Serves as a building block for creating specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as components for OLEDs or conductive polymers.
• Fluorine Chemistry Research: A valuable substrate for studying nucleophilic aromatic substitution and other reactions involving fluorinated aromatics.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs for the production of bespoke molecules for clinical trials and commercial scale-up.

Basic Information

Product Name	2,3-Difluoro-6-Methylpyridine
CAS No.	1227579-04-5
Molecular Formula	C6H5F2N
Molecular Weight	129.11 g/mol
Synonyms	6-Methyl-2,3-difluoropyridine; 2,3-Difluoro-6-picoline; 2,3-Difluoro-6-methylpyridine; 2,3-Difluoro-6-methyl-pyridine; 2,3-Difluor-6-methylpyridin; 6-Methyl-2,3-difluoro-pyridine
EINECS	Contact for details

Quality Control

Every batch of 2,3-Difluoro-6-Methylpyridine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the precise requirements for research and commercial synthesis. Our standard quality commitment includes HPLC purity ≥98% (typical), with detailed impurity profiling available. Certificates of Analysis (COA) are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong alkalis and incompatible materials. Due to its fluoride content, ensure containers are properly sealed and handled with appropriate engineering controls.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.