Description

4-Chloro-6-Fluoropyridin-3-Ol is a high-value halogenated pyridine derivative, a crucial building block in modern synthetic chemistry. Its unique substitution pattern makes it an essential intermediate for constructing complex molecules, particularly in the pharmaceutical and agrochemical sectors. This compound is primarily sought by R&D chemists and process development scientists for the synthesis of active pharmaceutical ingredients (APIs) and advanced crop protection agents.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, especially kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Building block for developing advanced herbicides, fungicides, and insecticides with improved efficacy.
• Material Science Research: Used in the development of specialty chemicals, ligands for catalysis, and functionalized polymers.
• Contract Research & Manufacturing (CRAM): Supplied to CROs and CDMOs for custom synthesis and scale-up projects.
• Academic Research: Utilized in university and institutional labs for methodological studies and exploring new chemical reactions.

Basic Information

Product Name	4-Chloro-6-Fluoropyridin-3-Ol
CAS No.	1227578-00-8
Molecular Formula	C5H3ClFNO
Molecular Weight	147.54 g/mol
Synonyms	3-Hydroxy-4-chloro-6-fluoropyridine; 4-Chloro-6-fluoro-3-hydroxypyridine; 4-Chloro-6-fluoro-3-pyridinol; 6-Fluoro-4-chloropyridin-3-ol; 4-Chloro-6-fluoro-3(1H)-pyridinone (tautomer); 4-Chloro-6-fluoropyridin-3-ol; 1227578-00-8
EINECS	Contact for details

Quality Control

Our 4-Chloro-6-Fluoropyridin-3-Ol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring full traceability and compliance with your internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.