Description

2-Chloro-3-Fluoropyridin-4-Amine is a high-purity, multi-functional halogenated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique substitution pattern makes it an indispensable intermediate for constructing complex molecules with tailored biological and physical properties. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in kinase inhibitor and antiviral research programs.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging its halogenated pyridine core.
• Material Science Precursor: Employed in the creation of specialized ligands for catalysis and functional materials.
• Chemical Research & Development: Serves as a versatile scaffold for medicinal chemistry and process chemistry optimization in laboratory settings.
• Custom Synthesis: A foundational component for contract research organizations (CROs) and CDMOs producing bespoke compounds for client projects.

Basic Information

Product Name	2-Chloro-3-Fluoropyridin-4-Amine
CAS No.	1227577-03-8
Molecular Formula	C5H4ClFN2
Molecular Weight	146.55 g/mol
Synonyms	4-Amino-2-chloro-3-fluoropyridine; 2-Chloro-3-fluoro-4-pyridinamine; 3-Fluoro-2-chloropyridin-4-amine; 2-Chloro-3-fluoropyridin-4-ylamine; 4-Pyridinamine, 2-chloro-3-fluoro-; 2-Chloro-3-fluoro-4-aminopyridine
EINECS	Contact for details

Quality Control

Our 2-Chloro-3-Fluoropyridin-4-Amine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.