Description

Methyl 6-Chloro-2-(Trifluoromethyl)Nicotinate is a high-purity, multi-functional chemical intermediate designed for advanced synthesis. Its core value lies in the strategic combination of a halogenated pyridine core and a trifluoromethyl group, offering unique reactivity and physicochemical properties for creating complex molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries seeking to incorporate these valuable motifs into new active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders, inflammation, and infectious diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Material Science Research: Serves as a precursor for creating specialized ligands, catalysts, and functionalized polymers with tailored electronic properties.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and contract research organizations (CROs/CMOs) developing proprietary compounds.

Basic Information

Product Name	Methyl 6-Chloro-2-(Trifluoromethyl)Nicotinate
CAS No.	1227575-31-6
Molecular Formula	C8H5ClF3NO2
Molecular Weight	239.58 g/mol
Synonyms	Methyl 6-chloro-2-(trifluoromethyl)pyridine-3-carboxylate; 6-Chloro-2-(trifluoromethyl)nicotinic acid methyl ester; 3-Pyridinecarboxylic acid, 6-chloro-2-(trifluoromethyl)-, methyl ester; Methyl 6-chloro-2-trifluoromethylnicotinate; 1227575-31-6
EINECS	Contact for details

Quality Control

Every batch of Methyl 6-Chloro-2-(Trifluoromethyl)Nicotinate is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure consistency and purity. Our standard grade meets specifications suitable for research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.