Description

Methyl 2-Chloro-3-(Trifluoromethyl)Isonicotinate is a high-value, multi-functional chemical building block characterized by its unique pyridine core substituted with chloro and trifluoromethyl groups. This compound matters for its critical role in facilitating complex molecular synthesis, particularly in the development of advanced active ingredients. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel compounds with targeted biological activity.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Research: Serves as a versatile scaffold for developing next-generation herbicides, fungicides, and insecticides, leveraging the bioactivity of the fluorinated pyridine moiety.
• Material Science Chemistry: Used in the research and development of specialty chemicals, including liquid crystals, organic semiconductors, and advanced polymers.
• Chemical Synthesis Building Block: The reactive ester and halogenated pyridine structure makes it ideal for cross-coupling reactions (e.g., Suzuki, Stille) and nucleophilic substitutions to construct complex heterocyclic systems.
• Contract Research & Development (CRO/CMO): Supplied to research organizations and custom synthesis manufacturers for client-directed projects and library synthesis.

Basic Information

Product Name	Methyl 2-Chloro-3-(Trifluoromethyl)Isonicotinate
CAS No.	1227575-06-5
Molecular Formula	C8H5ClF3NO2
Molecular Weight	239.58 g/mol
Synonyms	Methyl 2-chloro-3-(trifluoromethyl)pyridine-4-carboxylate; 2-Chloro-3-(trifluoromethyl)isonicotinic acid methyl ester; 4-Pyridinecarboxylic acid, 2-chloro-3-(trifluoromethyl)-, methyl ester; Methyl 2-chloro-3-trifluoromethylisonicotinate; 2-Chloro-3-trifluoromethyl-4-pyridinecarboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 2-Chloro-3-(Trifluoromethyl)Isonicotinate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with complete batch data are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.