Description

2-Fluoro-5-(trifluoromethyl)isonicotinic acid is a high-value fluorinated pyridine derivative, serving as a critical building block in modern synthetic chemistry. Its unique structure, featuring both fluorine and a trifluoromethyl group on the pyridine ring, makes it indispensable for modulating the physicochemical properties of target molecules. This advanced intermediate is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for creating novel active ingredients with enhanced metabolic stability, bioavailability, and lipophilicity.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in kinase inhibitor and antiviral research programs.
• Agrochemical Synthesis: Used in the creation of advanced herbicides and pesticides, where the fluorine atoms contribute to improved efficacy and environmental profile.
• Ligand & Catalyst Development: Serves as a precursor for sophisticated ligands in catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of specialty polymers and organic electronic materials requiring specific fluorinated motifs.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	2-Fluoro-5-(Trifluoromethyl)Isonicotinic Acid
CAS No.	1227574-99-3
Molecular Formula	C7H3F4NO2
Molecular Weight	209.10 g/mol
Synonyms	2-Fluoro-5-(trifluoromethyl)pyridine-4-carboxylic acid; 4-Pyridinecarboxylic acid, 2-fluoro-5-(trifluoromethyl)-; 2-Fluoro-5-trifluoromethylisonicotinic acid; 2-Fluoro-5-(trifluoromethyl)-4-pyridinecarboxylic acid; 5-(Trifluoromethyl)-2-fluoroisonicotinic acid; FTFA; 2-F-5-CF3-iNA
EINECS	Contact for details

Quality Control

Every batch of 2-Fluoro-5-(trifluoromethyl)isonicotinic acid is manufactured and tested under a strict quality management system. We ensure compliance with high-purity standards suitable for research and commercial synthesis. Comprehensive analytical testing, including HPLC, NMR, and MS, is performed to verify identity, purity, and consistency. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment to guarantee traceability and support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its nature as a strong acid/organic solvent, keep away from heat, sparks, and incompatible materials such as strong bases and oxidizing agents. Keep the container tightly sealed when not in use to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.