Description

3-Chloro-2-Fluoro-5-Methoxy-Pyridine is a high-purity, multi-functional heterocyclic building block essential for advanced chemical synthesis. Its unique halogenated pyridine structure makes it a critical intermediate for developing novel active ingredients in the pharmaceutical and agrochemical sectors. This compound is primarily sought by R&D chemists and process development scientists working on new drug candidates, crop protection agents, and specialty materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging its halogenated pyridine core.
• Material Science Research: Serves as a precursor for creating functionalized ligands, organic electronic materials, and liquid crystals.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions to create complex biaryl and heteroaryl structures.
• Contract Research & Manufacturing (CRAM): Supplied to CROs and CDMOs for custom synthesis and scale-up projects.
• Academic Research: Utilized in university and institutional labs for methodological studies in organic and medicinal chemistry.

Basic Information

Product Name	3-Chloro-2-Fluoro-5-Methoxy-Pyridine
CAS No.	1227574-55-1
Molecular Formula	C6H5ClFNO
Molecular Weight	161.56 g/mol
Synonyms	2-Fluoro-3-chloro-5-methoxypyridine; 5-Methoxy-3-chloro-2-fluoropyridine; 3-Chloro-2-fluoro-5-methoxypyridine; Pyridine, 3-chloro-2-fluoro-5-methoxy-; 1227574-55-1; 2-Fluoro-3-chloro-5-methoxy pyridine
EINECS	Contact for details

Quality Control

Our 3-Chloro-2-Fluoro-5-Methoxy-Pyridine is manufactured under strict quality management systems. We provide material with typical purities of ≥97% (by HPLC), tailored to meet the specific requirements of research and commercial-scale applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. Our quality commitment ensures consistency and reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.