Description

3-Bromomethyl-5-Chloro-2-Fluoropyridine is a high-value, multi-functional halogenated pyridine derivative serving as a critical building block in advanced organic synthesis. This compound is essential for researchers and manufacturers requiring precise molecular modifications to develop novel active compounds. It is primarily utilized in the pharmaceutical and agrochemical industries for the synthesis of complex molecules, including active pharmaceutical ingredients (APIs) and crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon for constructing complex heterocyclic scaffolds in drug discovery and development, particularly for candidates targeting central nervous system (CNS) disorders and infectious diseases.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the halogenated pyridine core contributes to biological activity and environmental stability.
• Material Science Precursor: Serves as a monomer or functionalization agent in the synthesis of specialty polymers, liquid crystals, and electronic materials.
• Cross-Coupling Reactions: The bromomethyl group is an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to introduce complex side chains.
• Ligand and Catalyst Development: Employed in the design and synthesis of novel ligands for catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Useful for labeling and modifying biomolecules in proteomics and diagnostic assay development due to its reactive halogen sites.

Basic Information

Product Name	3-Bromomethyl-5-Chloro-2-Fluoropyridine
CAS No.	1227574-00-6
Molecular Formula	C7H4BrClFN
Molecular Weight	244.47 g/mol
Synonyms	5-Chloro-2-fluoro-3-(bromomethyl)pyridine; 2-Fluoro-5-chloro-3-(bromomethyl)pyridine; 3-(Bromomethyl)-5-chloro-2-fluoropyridine; (5-Chloro-2-fluoropyridin-3-yl)methyl bromide; 2-Fluoro-5-chloro-3-pyridinemethyl bromide
EINECS	Contact for details

Quality Control

Our 3-Bromomethyl-5-Chloro-2-Fluoropyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification results. Our quality commitment ensures material consistency and reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in opaque or amber glass, or stored in dark conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.