Description

Ethyl 2-Hydroxy-5-(Trifluoromethyl)Isonicotinate is a high-value fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both a hydroxyl group and a trifluoromethyl substituent on the pyridine ring, makes it a versatile intermediate for creating complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of potential drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and infectious diseases.
• Agrochemical Synthesis: Used to develop advanced herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the development of organic electronic materials, such as charge-transport layers or fluorinated polymers.
• Chemical Biology Probes: Useful for synthesizing fluorescent tags or molecular probes for studying biological processes.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific research and scale-up projects.

Basic Information

Product Name	Ethyl 2-Hydroxy-5-(Trifluoromethyl)Isonicotinate
CAS No.	1227508-49-7
Molecular Formula	C9H8F3NO3
Molecular Weight	235.16 g/mol
Synonyms	Ethyl 2-hydroxy-5-(trifluoromethyl)pyridine-4-carboxylate; 5-(Trifluoromethyl)-2-hydroxypyridine-4-carboxylic acid ethyl ester; 4-Pyridinecarboxylic acid, 2-hydroxy-5-(trifluoromethyl)-, ethyl ester; 2-Hydroxy-5-trifluoromethylisonicotinic acid ethyl ester; Ethyl 2-hydroxy-5-(trifluoromethyl)isonicotinate; Isonicotinic acid, 2-hydroxy-5-(trifluoromethyl)-, ethyl ester
EINECS	Contact for details

Quality Control

Our Ethyl 2-Hydroxy-5-(Trifluoromethyl)Isonicotinate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide Certificates of Analysis (COA) with each shipment, detailing all specifications and test results to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be light-sensitive; prolonged exposure to light should be avoided. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.