Description

3-Chloromethyl-6-Fluoro-2-(Trifluoromethyl)Pyridine is a high-value, multi-functional halogenated pyridine derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring reactive chloromethyl and electron-withdrawing fluoro/trifluoromethyl groups, makes it indispensable for creating complex molecules with tailored properties. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and central nervous system (CNS) drug discovery programs.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and insecticides, where the fluorine and trifluoromethyl groups enhance biological activity and environmental stability.
• Ligand and Catalyst Precursor: Serves as a starting material for synthesizing specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Employed in the creation of functionalized polymers and advanced organic electronic materials due to its halogenated pyridine core.
• Custom Synthesis & Contract Manufacturing: A vital component for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	3-Chloromethyl-6-Fluoro-2-(Trifluoromethyl)Pyridine
CAS No.	1227502-18-2
Molecular Formula	C8H4ClF4N
Molecular Weight	225.57 g/mol
Synonyms	2-(Trifluoromethyl)-6-fluoro-3-pyridinemethanol, chloromethyl ether; 6-Fluoro-2-(trifluoromethyl)-3-pyridinylmethyl chloride; 3-(Chloromethyl)-6-fluoro-2-(trifluoromethyl)pyridine; 2-(Trifluoromethyl)-6-fluoro-3-(chloromethyl)pyridine; 6-Fluoro-2-trifluoromethyl-3-chloromethylpyridine; (6-Fluoro-2-(trifluoromethyl)pyridin-3-yl)methyl chloride
EINECS	Contact for details

Quality Control

Every batch of 3-Chloromethyl-6-Fluoro-2-(Trifluoromethyl)Pyridine is manufactured under strict quality management systems. Our products undergo rigorous quality testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure compliance with exacting industry standards and customer-specific requirements. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request and are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. Due to its light-sensitive nature, containers should be kept in secondary opaque packaging or amber glass.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.