Description

3-Chloro-2-Fluoropyridin-4-Ol is a high-value halogenated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique substitution pattern makes it an essential intermediate for constructing complex molecules with tailored biological and physical properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: Key synthon for the development of new drug candidates, particularly in kinase inhibitor and central nervous system (CNS) active compound libraries.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides and pesticides, leveraging its halogenated pyridine core.
• Material Science Precursor: Serves as a starting material for synthesizing specialized ligands, catalysts, and functionalized polymers.
• Chemical Research & Development: A versatile scaffold for medicinal chemistry, enabling structure-activity relationship (SAR) studies and lead optimization.
• Custom Synthesis: Employed in contract manufacturing organizations (CMOs) for the bespoke production of complex organic molecules for various industrial applications.

Basic Information

Product Name	3-Chloro-2-Fluoropyridin-4-Ol
CAS No.	1227499-28-6
Molecular Formula	C5H3ClFNO
Molecular Weight	147.54 g/mol
Synonyms	4-Hydroxy-3-chloro-2-fluoropyridine; 2-Fluoro-3-chloropyridin-4-ol; 3-Chloro-2-fluoro-4-hydroxypyridine; 3-Chloro-2-fluoro-4-pyridinol; 4-Pyridinol, 3-chloro-2-fluoro-; 2-Fluoro-3-chloro-4-pyridinol
EINECS	Contact for details

Quality Control

Every batch of 3-Chloro-2-Fluoropyridin-4-Ol is manufactured and tested under a strict quality management system. Our products undergo rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee compliance with your research and production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which may affect product stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.