Description

4-Bromo-2-Fluoro-3-(Trifluoromethyl)Pyridine CAS NO 1227496-58-3 is a high-value, multi-halogenated pyridine derivative serving as a critical building block in advanced organic synthesis. Its unique structure, featuring bromine, fluorine, and a trifluoromethyl group on the pyridine ring, makes it an indispensable intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by R&D and process chemistry teams in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and central nervous system (CNS) drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine and trifluoromethyl groups enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of functionalized polymers, liquid crystals, and electronic materials that require specific halogenated aromatic components.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Fluorinated Compound Libraries: A valuable reagent for medicinal chemistry teams building diverse compound libraries to explore structure-activity relationships (SAR).

Basic Information

Product Name	4-Bromo-2-Fluoro-3-(Trifluoromethyl)Pyridine
CAS No.	1227496-58-3
Molecular Formula	C7H2BrF4N
Molecular Weight	263.99 g/mol
Synonyms	4-Bromo-2-fluoro-3-(trifluoromethyl)pyridine; 2-Fluoro-4-bromo-3-(trifluoromethyl)pyridine; 3-(Trifluoromethyl)-4-bromo-2-fluoropyridine; 4-Bromo-2-fluoro-3-trifluoromethylpyridine; Pyridine, 4-bromo-2-fluoro-3-(trifluoromethyl)-; 1227496-58-3; 4-Br-2-F-3-CF3-Pyridine
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure batch-to-batch consistency and compliance with industry standards. We provide comprehensive analytical data including HPLC purity, NMR, and GC-MS for identity confirmation. Certificates of Analysis (COA) are available upon request for every batch, detailing all relevant specifications. Our quality management system is designed to meet the stringent requirements of research and pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.