Description

5-Bromo-2-(Chloromethyl)-3-Fluoropyridine is a high-value, multi-functional halogenated pyridine derivative serving as a critical building block in advanced organic synthesis. Its molecular structure, featuring bromine, chlorine, and fluorine substituents, makes it an exceptionally versatile intermediate for introducing specific halogenated motifs into target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the construction of complex active ingredients, where precise molecular modification is essential.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors, antiviral agents, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, leveraging its halogenated structure for bioactivity.
• Material Science Precursor: Serves as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and electronic materials.
• Cross-Coupling Reactions: The bromine atom is an excellent site for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille), enabling rapid diversification of molecular libraries.
• Nucleophilic Substitution: The reactive chloromethyl group allows for further functionalization through nucleophilic substitution, facilitating the attachment of various amines, alcohols, or thiols.
• Fluorine Chemistry Research: A valuable substrate for studying the effects of fluorine substitution on the physicochemical and biological properties of pyridine-based compounds.

Basic Information

Product Name	5-Bromo-2-(Chloromethyl)-3-Fluoropyridine
CAS No.	1227496-51-6
Molecular Formula	C6H4BrClFN
Molecular Weight	224.46 g/mol
Synonyms	3-Fluoro-5-bromo-2-(chloromethyl)pyridine; 2-(Chloromethyl)-5-bromo-3-fluoropyridine; 5-Bromo-3-fluoro-2-(chloromethyl)pyridine; 5-Bromo-2-chloromethyl-3-fluoropyridine; 1227496-51-6; 3-Fluoropyridine, 5-bromo-2-(chloromethyl)-
EINECS	Contact for details

Quality Control

Our 5-Bromo-2-(Chloromethyl)-3-Fluoropyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply and traceability for your most demanding projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.