Description

3-Bromo-2-(Chloromethyl)-6-Fluoropyridine is a high-purity, multi-functional halogenated pyridine derivative serving as a critical building block in advanced organic synthesis. This compound matters for its unique reactivity profile, offering distinct sites for nucleophilic substitution and cross-coupling reactions, which enables the efficient construction of complex molecular architectures. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging the fluorine and halogen substitutions for bioactivity.
• Material Science Precursor: Serves as a monomer or functionalization agent in the synthesis of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and Negishi cross-coupling reactions due to the bromine substituent, enabling carbon-carbon bond formation.
• Nucleophilic Substitution: The chloromethyl group provides a reactive handle for further functionalization with various nucleophiles like amines, thiols, and alkoxides.
• Chemical Research & Development: A versatile scaffold in medicinal and process chemistry for exploring new chemical spaces and optimizing synthetic routes.

Basic Information

Product Name	3-Bromo-2-(Chloromethyl)-6-Fluoropyridine
CAS No.	1227496-41-4
Molecular Formula	C6H4BrClFN
Molecular Weight	224.46 g/mol
Synonyms	2-(Chloromethyl)-3-bromo-6-fluoropyridine; 6-Fluoro-3-bromo-2-chloromethylpyridine; 3-Bromo-6-fluoro-2-pyridinylmethyl chloride; 3-Bromo-2-(chloromethyl)-6-fluoropyridine; Pyridine, 3-bromo-2-(chloromethyl)-6-fluoro-; 1227496-41-4; Halogenated pyridine building block
EINECS	Contact for details

Quality Control

Our 3-Bromo-2-(Chloromethyl)-6-Fluoropyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP compliance for pharmaceutical applications and can tailor purity grades to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.