Description

7-Cbz-2,7-Diaza-Spiro[3.5]Nonane Hydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic diaza structure. This compound is a critical building block in modern medicinal chemistry, enabling the synthesis of novel drug candidates with enhanced properties. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, particularly in the areas of central nervous system (CNS) and metabolic disease research.

Application

• Pharmaceutical Intermediate: A key scaffold for the synthesis of novel active pharmaceutical ingredients (APIs) targeting various disease pathways.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) and improve drug-like properties.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a versatile linker component due to its rigid spirocyclic core and functional handles.
• CNS Drug Discovery: Employed in the research and development of therapeutics for neurological and psychiatric disorders.
• Chemical Biology Probes: Utilized to create tool compounds for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied for bespoke synthesis projects requiring high-fidelity, complex heterocyclic building blocks.

Basic Information

Product Name	7-Cbz-2,7-Diaza-Spiro[3.5]Nonane Hydrochloride
CAS No.	1227382-15-1
Molecular Formula	C17H23N3O2 • HCl
Molecular Weight	337.85 g/mol (as free base: 301.38)
Synonyms	2,7-Diaza-spiro[3.5]nonane-7-carboxylic acid, 2-[(phenylmethoxy)carbonyl]-, hydrochloride (1:1); 2-[(Benzyloxy)carbonyl]-2,7-diazaspiro[3.5]nonane-7-carboxylic Acid Hydrochloride; 7-(Cbz)-2,7-Diazaspiro[3.5]nonane HCl; 7-N-Cbz-2,7-diazaspiro[3.5]nonane hydrochloride; Cbz-Protected 2,7-Diazaspiro[3.5]nonane HCl Salt; 2,7-Diazaspiro[3.5]nonane-2,7-dicarboxylic acid, 7-(phenylmethyl) ester, hydrochloride; 1227382-15-1
EINECS	Contact for details

Quality Control

Our 7-Cbz-2,7-Diaza-Spiro[3.5]Nonane Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring reliability for research and pre-clinical development phases.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity	≤ 0.5%
Total Impurities	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.