Description

1-(Phenylsulphonyl)-2-Chloro-4-Fluoro-7-Azaindole is a high-purity, advanced pharmaceutical intermediate characterized by its unique azaindole core functionalized with halogen and sulfonyl groups. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of targeted small-molecule therapeutics with enhanced potency and selectivity. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of kinase inhibitors and other novel drug candidates, particularly within oncology and inflammatory disease research pipelines.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of novel kinase inhibitors and other targeted therapeutic agents.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its versatile chemical scaffold.
• Chemical Biology Probes: Serves as a precursor for developing selective molecular probes to study enzyme function and signaling pathways.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services for the pharmaceutical industry.
• Academic Research: Utilized in university and institutional labs for exploratory synthetic chemistry and drug discovery projects.

Basic Information

Product Name	1-(Phenylsulphonyl)-2-Chloro-4-Fluoro-7-Azaindole
CAS No.	1227270-84-9
Molecular Formula	C13H8ClFN2O2S
Molecular Weight	310.73 g/mol
Synonyms	2-Chloro-4-fluoro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine; 2-Chloro-4-fluoro-1-(phenylsulfonyl)-7-azaindole; 1H-Pyrrolo[2,3-b]pyridine, 2-chloro-4-fluoro-1-(phenylsulfonyl)-; 1-(Phenylsulfonyl)-2-chloro-4-fluoro-7-azaindole; 2-Chloro-4-fluoro-1-(benzenesulfonyl)-1H-pyrrolo[2,3-b]pyridine
EINECS	Contact for details

Quality Control

Our 1-(Phenylsulphonyl)-2-Chloro-4-Fluoro-7-Azaindole is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, meeting the stringent requirements of pharmaceutical R&D. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant ICH guidelines for stability and impurity characterization to support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound should be kept under an inert atmosphere for long-term storage to ensure stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.