Description

4- Methyl-1 -(Phenylsulfonyl)-1 H-Pyrrolo[2,3-B]Pyridine is a high-purity, advanced pharmaceutical intermediate with the CAS number 1227270-73-6. This specialized heterocyclic sulfonamide compound is critical for the research and development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor programs. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers seeking a reliable and consistent supply of this key building block.

Application

• Pharmaceutical Intermediate: Serves as a core scaffold in the synthesis of targeted kinase inhibitors for oncology and inflammatory disease research.
• Medicinal Chemistry Research: Used as a versatile building block for structure-activity relationship (SAR) studies and lead optimization in drug discovery.
• Biochemical Probe Development: Employed in the creation of selective chemical probes to study specific biological pathways and protein functions.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and cGMP production of clinical trial materials.
• Academic Research: Utilized in university and institutional labs for fundamental research in heterocyclic and sulfonamide chemistry.

Basic Information

Product Name	4- Methyl-1 -(Phenylsulfonyl)-1 H-Pyrrolo[2,3-B]Pyridine
CAS No.	1227270-73-6
Molecular Formula	C15H12N2O2S
Molecular Weight	284.33 g/mol
Synonyms	1-(Phenylsulfonyl)-4-methyl-1H-pyrrolo[2,3-b]pyridine; 4-Methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine, 4-methyl-1-(phenylsulfonyl)-; 4-Methyl-1-tosyl-1H-pyrrolo[2,3-b]pyridine (common name); 1227270-73-6; 4-Methyl-1-(benzenesulfonyl)-1H-pyrrolo[2,3-b]pyridine
EINECS	Contact for details

Quality Control

Every batch of 4- Methyl-1 -(Phenylsulfonyl)-1 H-Pyrrolo[2,3-B]Pyridine is manufactured and tested under a strict quality management system. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency meet the exacting standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.