Description

Ethyl 2-Acetamido-2-(dimethoxyphosphoryl)acetate is a high-value organophosphorus building block, specifically a phosphonate derivative, essential for advanced synthetic chemistry. Its core value lies in enabling the synthesis of complex molecules, particularly in the development of novel pharmaceuticals and agrochemicals. This compound is primarily needed by research scientists and process chemists in the pharmaceutical, agrochemical, and fine chemical industries for constructing peptidomimetics and other biologically active scaffolds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting enzyme inhibition.
• Peptidomimetic Synthesis: Used to incorporate phosphonate moieties into peptide analogs, enhancing stability and bioactivity.
• Agrochemical Research: Serves as a building block for developing new herbicides, insecticides, or plant growth regulators with phosphonate activity.
• Chemical Biology Probes: Utilized in the creation of activity-based probes for studying enzymatic processes and signal transduction pathways.
• Ligand Development: Acts as a starting material for synthesizing chelating agents or catalysts used in asymmetric synthesis.
• Academic & Industrial R&D: Employed in research laboratories for methodological development and exploring new chemical spaces in medicinal chemistry.

Basic Information

Product Name	Ethyl 2-Acetamido-2-(dimethoxyphosphoryl)acetate
CAS No.	1227060-32-3
Molecular Formula	C9H18NO6P
Molecular Weight	267.22 g/mol
Synonyms	Ethyl (Acetamido(dimethoxyphosphoryl))acetate; Diethyl (Acetamidophosphono)acetate (common misnomer); 2-Acetamido-2-(dimethoxyphosphoryl)acetic acid ethyl ester; Ac-Gly(PO(OMe)2)-OEt; Phosphonoglycine derivative; N-Acetyl-α-(dimethoxyphosphinyl)glycine ethyl ester; (Acetamido(dimethoxyphosphoryl))acetic acid ethyl ester
EINECS	Contact for details

Quality Control

Our Ethyl 2-Acetamido-2-(dimethoxyphosphoryl)acetate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Typical 97-99%)
Water Content (KF)	≤ 1.0%
Solubility	Soluble in common organic solvents (e.g., DMSO, DMF, methanol)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.