Description

Methyl 2-Amino-5-(Trifluoromethyl)Nicotinate is a high-value trifluoromethylated pyridine derivative, serving as a critical synthetic intermediate in modern organic chemistry. Its core value lies in the unique combination of the electron-deficient pyridine core and the metabolically stable trifluoromethyl group, enabling the development of novel compounds with enhanced biological activity and physicochemical properties. This building block is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating new active ingredients in medicinal and crop protection chemistry.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially kinase inhibitors, antiviral agents, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the trifluoromethyl group improves lipophilicity and biological stability.
• Material Science Research: Serves as a building block for creating functionalized ligands, organic semiconductors, and specialty polymers.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme mechanisms and biological pathways.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	Methyl 2-Amino-5-(Trifluoromethyl)Nicotinate
CAS No.	1227048-89-6
Molecular Formula	C8H7F3N2O2
Molecular Weight	220.15 g/mol
Synonyms	2-Amino-5-(trifluoromethyl)nicotinic acid methyl ester; Methyl 2-amino-5-(trifluoromethyl)pyridine-3-carboxylate; 3-Pyridinecarboxylic acid, 2-amino-5-(trifluoromethyl)-, methyl ester; 2-Amino-5-trifluoromethyl-nicotinic acid methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 2-Amino-5-(Trifluoromethyl)Nicotinate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.