Description

tert-Butyl 2-Chloro-5-oxo-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate is a high-purity, advanced pharmaceutical intermediate of significant commercial interest. This compound serves as a critical building block in modern medicinal chemistry, enabling the synthesis of complex molecules with targeted biological activity. It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of novel active pharmaceutical ingredients (APIs), particularly within therapeutic areas requiring sophisticated heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new drug candidates, especially those containing the 1,6-naphthyridine core.
• API Synthesis: Used in the multi-step synthesis of potential Active Pharmaceutical Ingredients (APIs) for various therapeutic applications.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization processes in drug discovery.
• Chemical Biology Probes: Serves as a starting material for creating specialized molecular probes used to study biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.
• Academic Research: Utilized in university and institutional labs for methodological development and the exploration of new heterocyclic chemistry.

Basic Information

Product Name	tert-Butyl 2-Chloro-5-oxo-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate
CAS No.	1226898-92-5
Molecular Formula	C13H15ClN2O3
Molecular Weight	282.72 g/mol
Synonyms	6-(tert-Butoxycarbonyl)-2-chloro-5,7,8,9-tetrahydro-1,6-naphthyridin-5-one; 2-Chloro-6-[(2-methylpropan-2-yl)oxycarbonyl]-5,8-dihydro-1,6-naphthyridin-5(6H)-one; tert-Butyl 2-chloro-5-oxo-5,8-dihydro-1,6-naphthyridine-6(7H)-carboxylate; 2-Chloro-5-oxo-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylic acid tert-butyl ester; Boc-Protected 2-Chloro-1,6-naphthyridinone Derivative
EINECS	Contact for details

Quality Control

Our tert-Butyl 2-Chloro-5-oxo-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.