Description

Bromo-Peg2-Phosphonic Acid Ethyl Ester is a high-purity, functionalized PEG-phosphonate derivative designed for advanced chemical synthesis. This compound is a critical building block for creating custom linkers and modifying biomolecules, offering precise control over conjugation and surface properties. It is essential for researchers and manufacturers in the pharmaceutical, biotech, and materials science sectors who require reliable, high-quality intermediates for developing novel therapeutics, diagnostics, and functional materials.

Application

• Pharmaceutical Linker Chemistry: Serves as a versatile heterobifunctional linker for the site-specific conjugation of drugs, peptides, or imaging agents to antibodies, proteins, or nanoparticles.
• Proteolysis-Targeting Chimera (PROTAC) Development: Used in the synthesis of PROTAC molecules, where it can function as a component of the linker connecting the E3 ligase ligand to the target protein ligand.
• Surface Functionalization: Enables the modification of surfaces (e.g., gold, silica, polymers) with phosphonate anchoring groups for creating stable, biocompatible coatings.
• Bioconjugation Reagent: The bromo group allows for efficient alkylation of thiols or amines, while the phosphonate ester provides a handle for further modification or stable surface attachment.
• Polymer & Dendrimer Synthesis: Acts as a functional monomer or chain extender for creating polymers with tailored hydrophilicity, biodegradability, and reactive side chains.
• Chemical Biology Probes: Utilized in the design and synthesis of activity-based probes or affinity labels for studying enzyme function and protein interactions.

Basic Information

Product Name	Bromo-Peg2-Phosphonic Acid Ethyl Ester
CAS No.	1226767-94-7
Molecular Formula	C9H20BrO6P
Molecular Weight	335.13 g/mol
Synonyms	2-[2-(2-Bromoethoxy)ethoxy]ethylphosphonic acid diethyl ester; Diethyl (2-(2-(2-bromoethoxy)ethoxy)ethyl)phosphonate; Bromo-PEG2-phosphonate diethyl ester; (2-(2-(2-Bromoethoxy)ethoxy)ethyl)phosphonic acid diethyl ester; Ethyl 2-(2-(2-bromoethoxy)ethoxy)ethylphosphonate; Bromo-dPEG®2-phosphonic acid ethyl ester; Br-PEG2-P(O)(OEt)2; Bromo-triethylene glycol phosphonic acid diethyl ester
EINECS	Contact for details

Quality Control

Every batch of Bromo-Peg2-Phosphonic Acid Ethyl Ester is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from HPLC, NMR (¹H and ³¹P), and mass spectrometry. Our quality commitment ensures the material meets the stringent requirements for research and cGMP-grade pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Complies
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.