Description

5-(2-(Trifluoromethyl)Phenyl)Pyridin-3-Amine is a high-purity, advanced pharmaceutical intermediate characterized by its unique trifluoromethylphenyl-pyridine amine structure. This compound is of significant commercial importance for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular scaffolds. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecules with enhanced bioactivity and physicochemical properties.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, especially in oncology, CNS disorders, and anti-inflammatory therapies.
• Agrochemical Synthesis: Used in creating novel pesticides and herbicides, where the trifluoromethyl group can improve metabolic stability and lipophilicity.
• Ligand & Catalyst Development: Serves as a precursor for nitrogen-containing ligands in catalytic systems for asymmetric synthesis.
• Material Science Research: Employed in the development of organic electronic materials, such as charge-transport layers or emissive materials for OLEDs.
• Chemical Biology Probes: Utilized as a scaffold for designing molecular probes to study enzyme function and protein interactions.
• Custom Synthesis & Contract Manufacturing: A starting material for custom synthesis services catering to specific client R&D projects.

Basic Information

Product Name	5-(2-(Trifluoromethyl)Phenyl)Pyridin-3-Amine
CAS No.	1224740-83-3
Molecular Formula	C12H9F3N2
Molecular Weight	238.21 g/mol
Synonyms	3-Amino-5-[2-(trifluoromethyl)phenyl]pyridine; 5-(2-(Trifluoromethyl)phenyl)-3-pyridinamine; 5-(α,α,α-Trifluoro-o-tolyl)pyridin-3-amine; 3-Pyridinamine, 5-[2-(trifluoromethyl)phenyl]-; 1224740-83-3; 5-(2-Trifluoromethylphenyl)pyridin-3-ylamine
EINECS	Contact for details

Quality Control

Every batch of 5-(2-(Trifluoromethyl)Phenyl)Pyridin-3-Amine is manufactured under strict quality management systems. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with exacting industry standards and customer-specific requirements. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your regulatory and R&D documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is light-sensitive (store away from light). Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.