Description

Methyl 5,5,5-Trifluoro-4-(m-Tolylamino)Pentanoate is a high-value, fluorinated amino acid ester derivative that serves as a critical synthetic intermediate in advanced organic chemistry. This compound matters for its role in introducing the trifluoromethyl group and a chiral amino acid backbone, which are key motifs for modulating the biological activity and physicochemical properties of target molecules. Pharmaceutical researchers and agrochemical developers need this specialized building block for creating novel active ingredients, particularly in the synthesis of protease inhibitors, receptor modulators, and other bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel drug candidates, especially protease inhibitors and enzyme-targeted therapies.
• Agrochemical Research: Used in the development of advanced pesticides and herbicides, where the trifluoromethyl group enhances lipophilicity and metabolic stability.
• Fluorine Chemistry: Serves as a versatile precursor for introducing fluorinated segments into complex organic molecules in medicinal and materials chemistry.
• Peptidomimetics: Employed in the design and synthesis of peptide analogs with improved stability and bioavailability.
• Chemical Biology Probes: Utilized in the creation of tagged or modified molecules for studying biological pathways and target engagement.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs engaged in bespoke chemical synthesis for clients.

Basic Information

Product Name	Methyl 5,5,5-Trifluoro-4-(m-Tolylamino)Pentanoate
CAS No.	1224599-55-6
Molecular Formula	C14H16F3NO2
Molecular Weight	287.28 g/mol
Synonyms	Methyl 4-[(3-methylphenyl)amino]-5,5,5-trifluoropentanoate; 5,5,5-Trifluoro-4-[(3-methylphenyl)amino]pentanoic Acid Methyl Ester; 4-(m-Tolylamino)-5,5,5-trifluoropentanoic Acid Methyl Ester; Methyl 5,5,5-Trifluoro-4-(3-methylanilino)pentanoate; 1224599-55-6; Methyl 4-(3-methylphenylamino)-5,5,5-trifluoropentanoate
EINECS	Contact for details

Quality Control

Our Methyl 5,5,5-Trifluoro-4-(m-Tolylamino)Pentanoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and chiral analysis to ensure stereochemical integrity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment ensures the material meets the stringent requirements for research and development in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product is sensitive to strong bases and should be kept away from incompatible materials. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.