Description

5-Chloro-1-((2-(Trimethylsilyl)Ethoxy)Methyl)-1H-Pyrrolo[2,3-C]Pyridine-2-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate featuring a versatile pyrrolopyridine scaffold protected by a SEM (2-(trimethylsilyl)ethoxymethyl) group. This compound is critical for medicinal chemistry research and development, serving as a key building block in the synthesis of novel drug candidates targeting various therapeutic areas. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the development of kinase inhibitors and other small-molecule therapeutics.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of complex active pharmaceutical ingredients (APIs), particularly those with a pyrrolopyridine core.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Kinase Inhibitor Development: Serves as a key building block for the creation of novel kinase inhibitors, a major class of targeted cancer therapies.
• Chemical Biology Probes: Employed in the synthesis of specialized molecular probes for studying biological pathways and target validation.
• Custom Synthesis: Used by fine chemical suppliers for the contract manufacturing of bespoke compounds for client-specific R&D projects.
• Academic Research: Utilized in university and institutional laboratories for exploratory synthetic chemistry and novel heterocycle development.

Basic Information

Product Name	5-Chloro-1-((2-(Trimethylsilyl)Ethoxy)Methyl)-1H-Pyrrolo[2,3-C]Pyridine-2-Carboxylic Acid
CAS No.	1223748-24-0
Molecular Formula	C15H19ClN2O3Si
Molecular Weight	338.86 g/mol
Synonyms	5-Chloro-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid; 5-Chloro-1-SEM-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid; 1H-Pyrrolo[2,3-c]pyridine-2-carboxylic acid, 5-chloro-1-[[2-(trimethylsilyl)ethoxy]methyl]-; 1223748-24-0; 5-Chloro-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid; 5-Chloro-1-SEM-pyrrolo[2,3-c]pyridine-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our 5-Chloro-1-((2-(Trimethylsilyl)Ethoxy)Methyl)-1H-Pyrrolo[2,3-C]Pyridine-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports compliance with the stringent requirements of pharmaceutical R&D and cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the material should be stored under an inert atmosphere (e.g., nitrogen or argon) in a desiccated environment to prevent moisture absorption and degradation. Recommended long-term storage temperature is between 2°C and 8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.