Description

tert-Butyl 1-Thia-6-Azaspiro[3.3]heptane-6-carboxylate is a high-value, heterocyclic building block featuring a unique spirocyclic scaffold that combines sulfur and nitrogen heteroatoms. This compound is critical for medicinal chemistry research, enabling the rapid exploration of novel chemical space in drug discovery programs. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers for the synthesis of potential therapeutic agents, particularly in developing new small molecule inhibitors and modulators.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) and oncology targets.
• Medicinal Chemistry Scaffold: Used to construct diverse compound libraries for high-throughput screening (HTS) and structure-activity relationship (SAR) studies due to its three-dimensional, saturated structure.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a versatile linker or component in the design of bifunctional molecules for targeted protein degradation.
• Covalent Inhibitor Design: The thia-aza spirocyclic structure can be leveraged in the design of covalent inhibitors that target specific cysteine or other nucleophilic residues.
• Agrochemical Research: Employed as a building block in the synthesis of novel herbicides, fungicides, or insecticides with potentially new modes of action.
• Chemical Biology Probes: Useful for creating tool compounds to study biological pathways and protein function.

Basic Information

Product Name	tert-Butyl 1-Thia-6-Azaspiro[3.3]heptane-6-carboxylate
CAS No.	1223573-53-2
Molecular Formula	C10H17NO2S
Molecular Weight	215.31 g/mol
Synonyms	1-Thia-6-azaspiro[3.3]heptane-6-carboxylic acid, 1,1-dimethylethyl ester; 6-Boc-1-thia-6-azaspiro[3.3]heptane; tert-Butyl 1-thia-6-azaspiro[3.3]heptane-6-carboxylate; 1-Thia-6-azaspiro[3.3]heptane, 6-Boc-protected; Boc-1-thia-6-azaspiro[3.3]heptane; Spiro[thia-6-azabicyclo[3.1.0]hexane-6,1'-cyclopropane]-6-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 1-Thia-6-Azaspiro[3.3]heptane-6-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent chemical identity. Certificates of Analysis (COA) with full analytical data are provided for every shipment. We adhere to cGMP standards for pharmaceutical intermediates, ensuring traceability and reliability for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when prolonged exposure is anticipated to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.