Description

tert-Butyl 6-Bromo-1H-Pyrrolo[3,2-C]Pyridine-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a brominated pyrrolopyridine core. This compound is a critical building block for medicinal chemists, enabling the synthesis of novel, complex molecules for drug discovery programs. It is primarily utilized in the research and development of targeted therapeutics, particularly in oncology and CNS disorders.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of small molecule drug candidates, especially kinase inhibitors and other targeted therapies.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its versatile bromine handle for cross-coupling reactions.
• API Development: Serves as a building block in the development of Active Pharmaceutical Ingredients (APIs) for clinical trials.
• Chemical Biology Probes: Employed in the creation of molecular probes for studying biological pathways and target validation.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.
• Agrochemical Research: Potential application in the development of new agrochemicals, leveraging its heterocyclic structure.

Basic Information

Product Name	tert-Butyl 6-Bromo-1H-Pyrrolo[3,2-C]Pyridine-1-Carboxylate
CAS No.	1222809-40-6
Molecular Formula	C12H13BrN2O2
Molecular Weight	297.15 g/mol
Synonyms	6-Bromo-1-(tert-butoxycarbonyl)-1H-pyrrolo[3,2-c]pyridine; 1H-Pyrrolo[3,2-c]pyridine-1-carboxylic acid, 6-bromo-, 1,1-dimethylethyl ester; 6-Bromo-1-Boc-1H-pyrrolo[3,2-c]pyridine; tert-Butyl 6-bromo-1H-pyrrolo[3,2-c]pyridine-1-carboxylate; 6-Bromo-1H-pyrrolo[3,2-c]pyridine-1-carboxylic acid tert-butyl ester; Boc-6-Bromo-pyrrolo[3,2-c]pyridine; 1222809-40-6
EINECS	Contact for details

Quality Control

Our tert-Butyl 6-Bromo-1H-Pyrrolo[3,2-C]Pyridine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specifications and test results. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.