Description

7-Boc-10,10-Difluoro-2,7-Diazaspiro[4.5]Decane is a high-value, multifunctional spirocyclic building block featuring a protected diamine core and strategic fluorine substitution. This compound is engineered to serve as a critical intermediate in modern medicinal chemistry, enabling the synthesis of novel bioactive molecules with enhanced metabolic stability and binding affinity. It is primarily sought after by pharmaceutical R&D teams and advanced fine chemical manufacturers for the development of new drug candidates, particularly in therapeutic areas requiring sophisticated molecular scaffolds.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially in central nervous system (CNS) and oncology research.
• Proteolysis Targeting Chimera (PROTAC) Development: Utilized in constructing linkers and warhead components due to its spirocyclic rigidity and functional handles.
• Kinase Inhibitor Synthesis: Incorporated into molecular frameworks targeting specific kinase enzymes for cancer and inflammatory diseases.
• Peptidomimetic Chemistry: Serves as a constrained diamine surrogate to improve the pharmacological properties of peptide-based drug leads.
• Chemical Biology Probe Development: Used to create tool compounds for studying enzyme function and cellular pathways.
• Agrochemical Research: Potential intermediate in the discovery of new herbicides or fungicides with novel modes of action.
• Material Science: Exploration as a monomer or cross-linker for specialty polymers with unique properties.

Basic Information

Product Name	7-Boc-10,10-Difluoro-2,7-Diazaspiro[4.5]Decane
CAS No.	1221818-66-1
Molecular Formula	C13H22F2N2O2
Molecular Weight	276.33 g/mol
Synonyms	2,7-Diazaspiro[4.5]decane, 10,10-difluoro-7-[(1,1-dimethylethoxy)carbonyl]-; tert-Butyl 10,10-difluoro-2,7-diazaspiro[4.5]decane-7-carboxylate; 7-(tert-Butoxycarbonyl)-10,10-difluoro-2,7-diazaspiro[4.5]decane; Boc-10,10-difluoro-2,7-diazaspiro[4.5]decane; 10,10-Difluoro-7-Boc-2,7-diazaspiro[4.5]decane; 7-Boc-10,10-difluoro-2,7-diaza-spiro[4.5]decane; 1221818-66-1
EINECS	Contact for details

Quality Control

Our production of 7-Boc-10,10-Difluoro-2,7-Diazaspiro[4.5]Decane adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We employ advanced analytical techniques including HPLC, GC, NMR, and MS for verification. Our quality system is designed to meet the exacting standards of pharmaceutical development, and custom purity grades or analytical packages are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from strong acids/bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.