Description

3-Bromo-5-Fluoropyridine 1-Oxide is a high-value, multi-functional heterocyclic building block essential for advanced organic synthesis. This compound is particularly significant for introducing both bromo and fluoro substituents onto a pyridine N-oxide scaffold, enabling precise molecular modifications. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), especially in kinase inhibitor and central nervous system (CNS) drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging the bioactivity of halogenated pyridine derivatives.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as charge-transport layers or photoactive compounds.
• Cross-Coupling Reactions: The bromo substituent makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions.
• Functional Group Transformation: The N-oxide moiety allows for directed metalation and subsequent functionalization at specific positions on the pyridine ring.

Basic Information

Product Name	3-Bromo-5-Fluoropyridine 1-Oxide
CAS No.	1221793-60-7
Molecular Formula	C5H3BrFNO
Molecular Weight	191.99 g/mol
Synonyms	3-Bromo-5-fluoropyridine N-oxide; 5-Fluoro-3-bromopyridine 1-oxide; 3-Bromo-5-fluoropyridine oxide; Pyridine, 3-bromo-5-fluoro-, 1-oxide; 3-Br-5-F-Pyridine N-Oxide
EINECS	Contact for details

Quality Control

Our 3-Bromo-5-Fluoropyridine 1-Oxide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support cGMP and ISO standards for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere when not in use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.