Description

tert-Butyl 2-Oxo-1,4,8-Triazaspiro[4.5]Decane-8-Carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its complex spirocyclic and heterocyclic structure. This compound is of significant value in medicinal chemistry for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of therapeutic agents targeting central nervous system disorders and other complex diseases.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of complex drug candidates, particularly those with spirocyclic architectures.
• Medicinal Chemistry Research: Serves as a versatile scaffold for constructing novel chemical libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• API Development: Used in the research and process development of new Active Pharmaceutical Ingredients (APIs), especially for neurological and psychiatric applications.
• Contract Manufacturing (CDMO): Supplied to Contract Development and Manufacturing Organizations for cGMP production of clinical trial materials and commercial APIs.
• Proteolysis Targeting Chimera (PROTAC) Synthesis: Potential use as a component in the linker or ligand design for bifunctional degrader molecules.
• Chemical Biology Probes: Can be utilized to develop tool compounds for investigating biological pathways and target validation.

Basic Information

Item	Details
Product Name	tert-Butyl 2-Oxo-1,4,8-Triazaspiro[4.5]Decane-8-Carboxylate
CAS No.	1221792-93-3
Molecular Formula	C12H21N3O3
Molecular Weight	255.31 g/mol
Synonyms	8-Boc-2-oxo-1,4,8-triazaspiro[4.5]decane; tert-Butyl 2-oxo-1,4,8-triazaspiro[4.5]decane-8-carboxylate; 1,4,8-Triazaspiro[4.5]decane-8-carboxylic acid, 2-oxo-, 1,1-dimethylethyl ester; 2-Oxo-1,4,8-triazaspiro[4.5]decane-8-carboxylic acid tert-butyl ester; Boc-2-oxo-1,4,8-triazaspiro[4.5]decane
EINECS	Contact for details

Quality Control

Our tert-Butyl 2-Oxo-1,4,8-Triazaspiro[4.5]Decane-8-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production can adhere to cGMP guidelines for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.