Description

2-Methoxy-4-(Trifluoromethyl)Nicotinic Acid is a high-value, multi-functional chemical building block characterized by its nicotinic acid core and trifluoromethyl and methoxy substituents. This compound matters for its role as a critical intermediate in the synthesis of advanced pharmaceutical agents and agrochemicals, where its unique structure imparts desirable biological activity and metabolic stability. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Serves as a crucial building block for developing new-generation herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing properties of the trifluoromethyl group.
• Ligand and Catalyst Development: Used in the preparation of specialized ligands for metal-catalyzed cross-coupling reactions and other synthetic transformations in fine chemical production.
• Material Science Research: Investigated as a monomer or precursor for advanced polymeric materials with specific electronic or surface properties.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring this specific fluorinated nicotinic acid derivative.

Basic Information

Product Name	2-Methoxy-4-(Trifluoromethyl)Nicotinic Acid
CAS No.	1221792-53-5
Molecular Formula	C8H6F3NO3
Molecular Weight	221.13 g/mol
Synonyms	4-(Trifluoromethyl)-2-methoxynicotinic acid; 2-Methoxy-4-(trifluoromethyl)pyridine-3-carboxylic acid; 3-Pyridinecarboxylic acid, 2-methoxy-4-(trifluoromethyl)-; 2-Methoxy-4-trifluoromethylnicotinic acid; 1221792-53-5; 2-Methoxy-4-(trifluoromethyl)-3-pyridinecarboxylic acid
EINECS	Contact for details

Quality Control

Our 2-Methoxy-4-(Trifluoromethyl)Nicotinic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and process chemistry. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Specifications can be developed to meet specific customer requirements for custom synthesis projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The product is light-sensitive and should be stored away from light as indicated.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.