Description

8-Phenyl-1-Thia-4-Azaspiro[4.5]Decan-3-One is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic scaffold. This compound is of significant value for medicinal chemistry research and development, serving as a critical building block for novel active pharmaceutical ingredients (APIs). It is primarily sought by R&D teams and process chemists in the pharmaceutical and biotechnology industries for applications in drug discovery programs targeting central nervous system (CNS) disorders, metabolic diseases, and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the multi-step synthesis of novel drug candidates, particularly those with spirocyclic or constrained heterocyclic architectures.
• Medicinal Chemistry Research: Used as a scaffold for structure-activity relationship (SAR) studies and library synthesis to explore new chemical space and identify lead compounds.
• API Development: Employed in the process research and scale-up stages for developing new Active Pharmaceutical Ingredients (APIs), especially for neurological and psychiatric targets.
• Chemical Biology Probe: Serves as a starting material for creating specialized molecular probes to study biological pathways and protein functions.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and development services for the pharmaceutical industry.
• Academic Research: Utilized in university and institutional labs for advanced synthetic organic chemistry projects and methodology development.

Basic Information

Product Name	8-Phenyl-1-Thia-4-Azaspiro[4.5]Decan-3-One
CAS No.	1221791-99-6
Molecular Formula	C17H21NOS
Molecular Weight	287.42 g/mol
Synonyms	8-Phenyl-1-thia-4-azaspiro[4.5]decan-3-one; 1-Thia-4-azaspiro[4.5]decan-3-one, 8-phenyl-; Spiro[cyclohexane-1,3'-thiazolidin]-2'-one, 5'-phenyl-; 5'-Phenylspiro[cyclohexane-1,3'-thiazolidin]-2'-one; 8-Phenyl-1-thia-4-azaspiro[4.5]decan-3-one (primary IUPAC); Advanced spirocyclic thiazolidinone intermediate
EINECS	Contact for details

Quality Control

Our 8-Phenyl-1-Thia-4-Azaspiro[4.5]Decan-3-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and MS, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and full analytical data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.