Description

2,2-(4,6-Dichloro-5-Methoxy-1,3-Phenylene)Bis(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane)(Wxc02280) is a high-purity, advanced pharmaceutical intermediate and key building block in organic synthesis. This compound is critical for enabling efficient cross-coupling reactions, particularly the Suzuki-Miyaura reaction, which is fundamental to modern drug discovery and materials science. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors to construct complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, especially those containing complex biaryl structures.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic ester reagent for palladium-catalyzed carbon-carbon bond formation, essential for creating novel chemical entities.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides requiring specific chlorinated aromatic motifs.
• Materials Science Research: Employed in the development of organic electronic materials, such as polymers for OLEDs and organic photovoltaics.
• Chemical Biology & Probe Development: Useful for creating tagged molecules and bioconjugates for diagnostic and research applications.
• Process Chemistry & Scale-Up: Provides a reliable and consistent building block for optimizing synthetic routes from laboratory to pilot plant scale.

Basic Information

Product Name	2,2-(4,6-Dichloro-5-Methoxy-1,3-Phenylene)Bis(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane)(Wxc02280)
CAS No.	1221589-79-2
Molecular Formula	C22H32B2Cl2O6
Molecular Weight	485.01 g/mol
Synonyms	4,6-Dichloro-5-methoxy-1,3-phenylenebis(boronic acid) bis(pinacol ester); 1,3-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4,6-dichloro-5-methoxybenzene; 4,6-Dichloro-5-methoxybenzene-1,3-diyldiboronic acid bis(pinacol) ester; WXC-02280; Wxc02280; 2,2'-(4,6-Dichloro-5-methoxy-1,3-phenylene)bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolane); 4,6-Dichloro-5-methoxy-m-phenylenebis(boronic acid pinacol ester)
EINECS	Contact for details

Quality Control

Every batch of 2,2-(4,6-Dichloro-5-Methoxy-1,3-Phenylene)Bis(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane) undergoes rigorous analytical testing to ensure it meets the high-purity standards required for sensitive cross-coupling reactions. Our quality assurance protocol includes HPLC, NMR, and GC-MS analysis to verify identity, potency, and impurity profiles. Certificates of Analysis (COA) documenting full specifications are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.