Description

3-(Trifluoromethoxy)Picolinic Acid is a high-value, fluorinated heterocyclic building block characterized by its picolinic acid core and trifluoromethoxy substituent. This compound matters as a critical intermediate in modern pharmaceutical and agrochemical research, where its unique structure imparts desirable properties like metabolic stability and enhanced lipophilicity to target molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced material sectors for synthesizing novel active ingredients and functional compounds.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging the trifluoromethoxy group for efficacy.
• Ligand in Catalysis: Serves as a precursor for creating specialized ligands in transition metal catalysis for asymmetric synthesis.
• Material Science Research: Employed in the synthesis of fluorinated organic compounds for electronic materials and liquid crystals.
• Chemical Biology Probes: Useful for constructing molecular probes and tags to study biological processes.

Basic Information

Item	Details
Product Name	3-(Trifluoromethoxy)Picolinic Acid
CAS No.	1221171-81-8
Molecular Formula	C7H4F3NO3
Molecular Weight	207.11 g/mol
Synonyms	3-(Trifluoromethoxy)pyridine-2-carboxylic acid; 2-Pyridinecarboxylic acid, 3-(trifluoromethoxy)-; Picolinic acid, 3-(trifluoromethoxy)-; 3-Trifluoromethoxypicolinic acid; 3-(Trifluoromethoxy)-2-pyridinecarboxylic acid
EINECS	Contact for details

Quality Control

Our 3-(Trifluoromethoxy)Picolinic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.