Description

2-Chloro-3-Trifluoromethoxy-Isonicotinic Acid is a high-value, multi-functional chemical intermediate characterized by its unique halogenated pyridine core. This compound matters for its role as a critical building block in the synthesis of advanced active ingredients, particularly in the pharmaceutical and agrochemical sectors. It is primarily needed by R&D chemists and process development scientists working on novel drug candidates, crop protection agents, and specialty materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for molecules targeting central nervous system (CNS) disorders and infectious diseases.
• Agrochemical Synthesis: Serves as a core scaffold for developing new-generation herbicides and insecticides with improved efficacy and environmental profiles.
• Ligand and Catalyst Development: Used in organometallic chemistry to create novel ligands for catalytic systems and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the development of specialty polymers and advanced electronic materials due to its fluorine-containing moiety.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke synthesis projects.

Basic Information

Product Name	2-Chloro-3-Trifluoromethoxy-Isonicotinic Acid
CAS No.	1221171-78-3
Molecular Formula	C7H3ClF3NO3
Molecular Weight	241.55 g/mol
Synonyms	2-Chloro-3-(trifluoromethoxy)isonicotinic acid; 2-Chloro-3-(trifluoromethoxy)pyridine-4-carboxylic acid; 4-Pyridinecarboxylic acid, 2-chloro-3-(trifluoromethoxy)-; Isonicotinic acid, 2-chloro-3-trifluoromethoxy-; 1221171-78-3; 2-Chloro-3-trifluoromethoxy-isonicotinic acid
EINECS	Contact for details

Quality Control

Our 2-Chloro-3-Trifluoromethoxy-Isonicotinic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed and away from direct light sources to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Assay	97.0% - 102.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.