Description

2-Chloro-5-(Trifluoromethoxy)Isonicotinic Acid is a high-value, multifunctional heterocyclic building block and intermediate in advanced organic synthesis. This compound is critical for the development of novel active ingredients, particularly in the pharmaceutical and agrochemical sectors, due to its unique combination of halogen and trifluoromethoxy substituents. It is primarily sought after by research institutions and industrial manufacturers engaged in the synthesis of complex molecules for drug discovery and crop protection agents.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Serves as a crucial building block for developing next-generation herbicides, fungicides, and insecticides with enhanced efficacy and environmental profiles.
• Material Science Research: Used in the creation of novel organic ligands, polymers, and liquid crystals where the introduction of specific halogenated motifs is required.
• Chemical Biology & Proteomics: Employed as a molecular scaffold or tagging agent in the design of chemical probes and enzyme inhibitors for biological research.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and scaled-up processes.

Basic Information

Product Name	2-Chloro-5-(Trifluoromethoxy)Isonicotinic Acid
CAS No.	1221171-77-2
Molecular Formula	C7H3ClF3NO3
Molecular Weight	241.55 g/mol
Synonyms	2-Chloro-5-(trifluoromethoxy)pyridine-4-carboxylic acid; 4-Pyridinecarboxylic acid, 2-chloro-5-(trifluoromethoxy)-; 2-Chloro-5-(trifluoromethoxy)isonicotinate; Isonicotinic acid, 2-chloro-5-(trifluoromethoxy)-; 1221171-77-2; 2-Chloro-5-trifluoromethoxy-isonicotinic acid
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-5-(Trifluoromethoxy)Isonicotinic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and commercial synthesis. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles by HPLC, NMR, and MS is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its nature as a strong acid/organic solvent, keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.