Description

4-(1-Isopropyl-1H-Pyrrolo[2,3-C]Pyridin-3-Yl)Pyrimidin-2-Amine is a high-purity, advanced pharmaceutical intermediate belonging to the pyrrolopyridine chemical class. This compound is of significant commercial interest for its role as a key building block in the synthesis of novel, targeted therapeutic agents. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of kinase inhibitors and other small-molecule drugs.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs), particularly for oncology and inflammatory disease targets.
• Kinase Inhibitor Research: Serves as a core scaffold for the design and development of potent and selective kinase inhibitors due to its privileged heterocyclic structure.
• Medicinal Chemistry & Drug Discovery: Used in lead optimization and structure-activity relationship (SAR) studies to improve drug candidate efficacy and pharmacokinetic properties.
• Biochemical Assay Development: Employed as a reference standard or probe compound in high-throughput screening and biochemical assays.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for clinical trial materials.

Basic Information

Product Name	4-(1-Isopropyl-1H-Pyrrolo[2,3-C]Pyridin-3-Yl)Pyrimidin-2-Amine
CAS No.	1221153-78-1
Molecular Formula	C14H15N5
Molecular Weight	253.30 g/mol
Synonyms	4-(1-Isopropyl-1H-pyrrolo[2,3-c]pyridin-3-yl)pyrimidin-2-amine; 2-Pyrimidinamine, 4-[1-(1-methylethyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-; UNII-9J3U8Q85VW; 9J3U8Q85VW; 4-(1-Isopropyl-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-pyrimidinamine; 4-(1-Isopropyl-1H-pyrrolo[2,3-c]pyridin-3-yl)pyrimidin-2-ylamine
EINECS	Contact for details

Quality Control

Our production of 4-(1-Isopropyl-1H-Pyrrolo[2,3-C]Pyridin-3-Yl)Pyrimidin-2-Amine adheres to stringent quality management systems, ensuring batch-to-batch consistency for critical R&D and cGMP manufacturing applications. Each lot is fully characterized and tested against comprehensive specifications using advanced analytical techniques including HPLC, GC, NMR, and MS. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.