Description

n-Isopropyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Amine is a high-value, functionalized pyridine derivative featuring a pinacol boronate ester group, making it a critical intermediate for advanced organic synthesis. This compound is essential for facilitating efficient carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone of modern pharmaceutical and agrochemical development. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly in kinase inhibitor and other small-molecule therapeutic programs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that require complex heterocyclic cores.
• Material Science Research: Serves as a precursor for creating organic electronic materials, ligands for catalysts, and functional polymers.
• Suzuki-Miyaura Cross-Coupling: The pinacol boronate ester group is specifically designed for palladium-catalyzed cross-coupling with aryl or vinyl halides, enabling precise molecular construction.
• Chemical Biology & Proteomics: Utilized in the development of molecular probes and bioconjugation reagents for target identification and validation.
• Academic & Contract Research: A valuable reagent for methodological development and synthetic chemistry research in academic and CRO (Contract Research Organization) laboratories.

Basic Information

Product Name	n-Isopropyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Amine
CAS No.	1220696-30-9
Molecular Formula	C14H23BN2O2
Molecular Weight	262.16 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-N-(propan-2-yl)pyridin-2-amine; 2-Amino-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine, N-isopropyl derivative; N-Isopropyl-5-(pinacolatoboryl)pyridin-2-amine; 5-(Pinacolatoboran-2-yl)-N-isopropylpyridin-2-amine; 2-Pyridinamine, 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-N-(1-methylethyl)-; 1220696-30-9; Boronic acid, B-[6-[(1-methylethyl)amino]-3-pyridinyl]-, pinacol ester
EINECS	Contact for details

Quality Control

Our n-Isopropyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Amine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, it is recommended to handle and store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term stability, especially after opening the original packaging. Recommended storage temperature: 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.