Description

(4-Hydroxy-1-Piperidinyl)(4,5,6,7-Tetrahydro-1H-Pyrazolo[4,3-C]Pyridin-3-Yl)Methanone Hcl is a high-purity, advanced pharmaceutical intermediate with the CAS number 1220033-85-1. This compound is a critical building block in modern medicinal chemistry, valued for its complex heterocyclic structure which serves as a key pharmacophore. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, particularly within central nervous system (CNS) and metabolic disorder research pipelines.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• CNS Drug Development: Employed in the synthesis of potential therapeutics targeting neurological and psychiatric conditions.
• Kinase Inhibitor Synthesis: Serves as a building block for compounds designed to modulate kinase activity, relevant in oncology and inflammatory diseases.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services.
• Academic Research: Utilized in university and institutional labs for fundamental studies in organic synthesis and pharmacology.

Basic Information

Product Name	(4-Hydroxy-1-Piperidinyl)(4,5,6,7-Tetrahydro-1H-Pyrazolo[4,3-C]Pyridin-3-Yl)Methanone Hydrochloride
CAS No.	1220033-85-1
Molecular Formula	C12H18N4O2 • HCl
Molecular Weight	286.76 g/mol (Free base: 250.30 g/mol)
Synonyms	4-Hydroxy-1-piperidinyl(4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl)methanone hydrochloride; 1H-Pyrazolo[4,3-c]pyridine, 4,5,6,7-tetrahydro-3-[(4-hydroxy-1-piperidinyl)carbonyl]-, hydrochloride; (4-Hydroxy-piperidin-1-yl)-(4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl)-methanone hydrochloride; 1220033-85-1; UNII-8S8I7P9Q2F; 8S8I7P9Q2F
EINECS	Contact for details

Quality Control

Our (4-Hydroxy-1-Piperidinyl)(4,5,6,7-Tetrahydro-1H-Pyrazolo[4,3-C]Pyridin-3-Yl)Methanone Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under inert conditions if the container is opened repeatedly to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.