Description

2-[2-(4-Piperidinyl)Ethoxy]-5-(Trifluoromethyl)-Pyridine Hydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its piperidine and trifluoromethylpyridine moieties. This compound is of significant commercial value for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology research. It is primarily sought by pharmaceutical R&D laboratories, contract research and manufacturing organizations (CROs/CMOs), and fine chemical suppliers serving the global life sciences sector.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of potential drug candidates, especially for neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its unique chemical scaffold.
• API Development: Serves as a building block for the development of new Active Pharmaceutical Ingredients (APIs) targeting specific receptors.
• Contract Manufacturing: Supplied to CMOs for scale-up synthesis under cGMP conditions for clinical trial material production.
• Reference Standard: Can be utilized as a high-purity analytical standard for quality control and method development.
• Biochemical Research: Employed in biochemical assays and as a tool compound for probing biological pathways.

Basic Information

Product Name	2-[2-(4-Piperidinyl)Ethoxy]-5-(Trifluoromethyl)-Pyridine Hydrochloride
CAS No.	1220030-39-6
Molecular Formula	C13H17F3N2O•HCl
Molecular Weight	309.74 g/mol (Free base: 274.29 g/mol)
Synonyms	5-(Trifluoromethyl)-2-[2-(4-piperidinyl)ethoxy]pyridine hydrochloride; 2-[2-(4-Piperidinyl)ethoxy]-5-(trifluoromethyl)pyridine HCl; 4-[2-[5-(Trifluoromethyl)-2-pyridinyl]oxy]ethyl]piperidine hydrochloride; UNII-9K3C8S2A8B; 1220030-39-6; 2-(2-(Piperidin-4-yl)ethoxy)-5-(trifluoromethyl)pyridine hydrochloride
EINECS	Contact for details

Quality Control

Our 2-[2-(4-Piperidinyl)Ethoxy]-5-(Trifluoromethyl)-Pyridine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) is provided with every shipment, detailing all specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.