Description

3-Pyrrolidinylmethyl 5-(Trifluoromethyl)-2-Pyridinyl Ether Hydrochloride is a high-purity, advanced pharmaceutical intermediate of significant commercial interest. Its core value lies in its role as a key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas targeting the central nervous system. This compound is essential for research institutions and pharmaceutical manufacturers engaged in drug discovery and process development, where reliable access to high-quality intermediates is critical for project timelines and regulatory success.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly for neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its unique pyrrolidinyl and trifluoromethylpyridinyl motifs.
• API Development: Serves as a key chiral building block in the multi-step synthesis of complex target molecules for preclinical and clinical development.
• Contract Manufacturing (CMO): Supplied to contract research and manufacturing organizations (CROs/CMOs) for custom synthesis and scale-up projects.
• Biochemical Tool Compound: Potential use in developing probes for studying biological targets such as enzymes and receptors in biochemical assays.

Basic Information

Product Name	3-Pyrrolidinylmethyl 5-(Trifluoromethyl)-2-Pyridinyl Ether Hydrochloride
CAS No.	1220016-81-8
Molecular Formula	C12H14F3N2O • HCl
Molecular Weight	294.71 g/mol (Free base: 258.25 g/mol)
Synonyms	5-(Trifluoromethyl)-2-((3-pyrrolidinylmethoxy)pyridine Hydrochloride; 2-((Pyrrolidin-3-yl)methoxy)-5-(trifluoromethyl)pyridine Hydrochloride; 3-Pyrrolidinylmethyl 5-Trifluoromethyl-2-pyridyl Ether HCl; 5-(Trifluoromethyl)-2-((3-pyrrolidinylmethyl)oxy)pyridine Hydrochloride; 1220016-81-8; UNII-9F4J6T5K6F; 9F4J6T5K6F
EINECS	Contact for details

Quality Control

Our 3-Pyrrolidinylmethyl 5-(Trifluoromethyl)-2-Pyridinyl Ether Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral purity, NMR and MS for structural confirmation, and KF titration for water content. We provide full traceability and detailed Certificates of Analysis (COA) to support your regulatory filings and ensure consistency for your critical R&D and cGMP manufacturing processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability and purity. Keep the container tightly sealed in a desiccator when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.