Description

2-(3-Pyrrolidinyloxy)-5-(Trifluoromethyl)Pyridinehydrochloride CAS NO 1220016-29-4 is a high-purity, advanced pharmaceutical intermediate characterized by its unique pyrrolidinyloxy and trifluoromethyl pyridine structure. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel active pharmaceutical ingredients (APIs) targeting central nervous system and other therapeutic areas. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers seeking a reliable and high-quality building block for complex synthetic pathways.

Application

• Pharmaceutical Intermediate: A key building block in the research and synthesis of novel drug candidates, particularly for neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its privileged scaffold.
• Active Pharmaceutical Ingredient (API) Development: Serves as a precursor in the multi-step synthesis of potential APIs, leveraging the trifluoromethyl group for enhanced metabolic stability and bioavailability.
• Contract Manufacturing (CMO): Supplied to contract manufacturing organizations for scale-up and cGMP production of clinical trial materials.
• Biochemical Research: Employed as a tool compound in biochemical assays and for probing specific biological targets and pathways.
• Fine Chemical Synthesis: Used in the preparation of more complex, functionalized molecules for various specialty chemical applications.

Basic Information

Product Name	2-(3-Pyrrolidinyloxy)-5-(Trifluoromethyl)Pyridinehydrochloride
CAS No.	1220016-29-4
Molecular Formula	C10H12ClF3N2O
Molecular Weight	268.66 g/mol
Synonyms	5-(Trifluoromethyl)-2-(3-pyrrolidinyloxy)pyridine hydrochloride; 2-(Pyrrolidin-3-yloxy)-5-(trifluoromethyl)pyridine HCl; 2-(3-Pyrrolidinyloxy)-5-(trifluoromethyl)pyridine monohydrochloride; 5-Trifluoromethyl-2-(3-pyrrolidinyloxy)pyridine hydrochloride; Pyrrolidine, 3-[(5-(trifluoromethyl)-2-pyridinyl)oxy]-, hydrochloride (1:1); 1220016-29-4
EINECS	Contact for details

Quality Control

Every batch of 2-(3-Pyrrolidinyloxy)-5-(Trifluoromethyl)Pyridinehydrochloride is manufactured and tested under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency meet the exacting standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing all test results and specifications is provided with each shipment to guarantee traceability and compliance with your internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. For long-term storage, consider desiccated or nitrogen-purged environments.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.