Description

N2-(Tetrahydro-2H-Pyran-4-Ylmethyl)-2,3-Pyridinediamine is a high-purity, advanced pharmaceutical intermediate with a distinct pyridine-pyran structural motif. This compound matters for its critical role as a sophisticated building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex molecular architectures. Pharmaceutical R&D teams and fine chemical manufacturers need this high-value intermediate to develop next-generation small molecule drugs targeting a range of diseases.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex small molecule APIs, especially for central nervous system (CNS) and oncology targets.
• Chemical Research & Development: Serves as a versatile scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Process Chemistry: Used in the development and scale-up of synthetic routes for novel therapeutic compounds under GMP conditions.
• Academic Research: Employed in university and institutional labs for studying heterocyclic chemistry and developing new synthetic methodologies.
• Contract Manufacturing (CDMO): Supplied to contract development and manufacturing organizations for custom synthesis projects.
• Pre-clinical Drug Development: Integral in the synthesis of candidate molecules for pharmacological screening and pre-clinical evaluation.

Basic Information

Product Name	N2-(Tetrahydro-2H-Pyran-4-Ylmethyl)-2,3-Pyridinediamine
CAS No.	1219976-68-7
Molecular Formula	C11H17N3O
Molecular Weight	207.27 g/mol
Synonyms	2,3-Pyridinediamine, N2-[(tetrahydro-2H-pyran-4-yl)methyl]-; N2-[(Tetrahydro-2H-pyran-4-yl)methyl]pyridine-2,3-diamine; 2-[(Oxan-4-yl)methyl]pyridine-2,3-diamine; 2,3-Diaminopyridine derivative; THP-protected diaminopyridine; Pyranylmethylpyridinediamine; 1219976-68-7; CAS 1219976-68-7
EINECS	Contact for details

Quality Control

Our N2-(Tetrahydro-2H-Pyran-4-Ylmethyl)-2,3-Pyridinediamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports compliance in regulated environments, and custom purity grades (e.g., >98%, >99%) are available to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.