Description

2-Methoxy-5-Nitropyridine-3-Boronic Acid Pinacol Ester is a high-value, multifunctional chemical building block essential for modern synthetic chemistry. This compound matters because it combines a protected boronic acid group with a nitropyridine scaffold, enabling precise cross-coupling reactions for constructing complex molecules. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Used to construct complex heterocyclic structures found in advanced herbicides, fungicides, and insecticides.
• Material Science Research: Serves as a building block for creating functionalized polymers, liquid crystals, and organic electronic materials.
• Chemical Biology Probes: Utilized in the development of tagged molecules and probes for studying biological pathways and protein interactions.
• Custom Synthesis & Contract Manufacturing: A critical reagent for CROs and CDMOs offering bespoke chemical synthesis services to global clients.

Basic Information

Product Name	2-Methoxy-5-Nitropyridine-3-Boronic Acid Pinacol Ester
CAS No.	1218791-18-4
Molecular Formula	C₁₂H₁₇BN₂O₅
Molecular Weight	280.09 g/mol
Synonyms	2-Methoxy-5-nitro-3-pyridineboronic acid pinacol ester; 5-Nitro-2-methoxypyridine-3-boronic acid pinacol ester; (2-Methoxy-5-nitropyridin-3-yl)boronic acid pinacol ester; 3-Borono-2-methoxy-5-nitropyridine pinacol ester; PINACOL 2-METHOXY-5-NITROPYRIDINE-3-BORONATE; 1218791-18-4; 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-methoxy-5-nitropyridine
EINECS	Contact for details

Quality Control

Our 2-Methoxy-5-Nitropyridine-3-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high purity and batch-to-batch consistency suitable for sensitive coupling reactions. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and reactivity.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.