Description

tert-Butyl(3-Chloro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenoxy)Dimethylsilane is a high-value organoboron and organosilicon hybrid building block, essential for advanced synthetic chemistry. Its core value lies in enabling precise Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecular architectures. This compound is critically needed by R&D and process development teams in the pharmaceutical, agrochemical, and materials science industries for creating novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly in oncology and CNS research.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides requiring specific aryl-aryl linkages.
• Organic Light-Emitting Diode (OLED) Materials: Serves as a precursor for creating advanced electron-transport or emissive layer materials in display technology.
• Polymer & Material Science: Enables the incorporation of functional aromatic units into polymers for enhanced thermal stability or electronic properties.
• Ligand & Catalyst Development: Utilized in the synthesis of sophisticated ligands for transition metal catalysis.
• Chemical Biology & Probe Synthesis: Acts as a versatile handle for bioconjugation and the creation of molecular probes for diagnostic applications.

Basic Information

Product Name	tert-Butyl(3-Chloro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenoxy)Dimethylsilane
CAS No.	1218789-46-8
Molecular Formula	C18H30BClO3Si
Molecular Weight	368.78 g/mol
Synonyms	2-(3-Chloro-5-((tert-butyldimethylsilyl)oxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-Chloro-5-((tert-butyldimethylsilyl)oxy)phenylboronic acid pinacol ester; tert-Butyldimethyl((3-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)oxy)silane; (3-Chloro-5-((tert-butyldimethylsilyl)oxy)phenyl)boronic acid pinacol ester; TBS-protected 3-chloro-5-boronic acid pinacol ester; B-(3-Chloro-5-((tert-butyldimethylsilyl)oxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our production of tert-Butyl(3-Chloro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenoxy)Dimethylsilane adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for critical synthetic applications. Each lot is analyzed via NMR (1H, 13C, 11B), HPLC, and GC to verify identity, purity, and impurity profile. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C in a cool, dry, and well-ventilated place. Keep away from heat, sparks, and open flame. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.