Description

(S)-α-(2-Pyridinylmethyl)-Pro2Hcl is a chiral, non-natural amino acid derivative of significant interest in advanced organic synthesis. This compound matters as a high-value building block for constructing complex molecules with precise stereochemistry, which is critical for developing bioactive compounds. It is primarily needed by pharmaceutical R&D teams, agrochemical researchers, and specialty chemical manufacturers focused on creating novel peptides, enzyme inhibitors, and chiral catalysts.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for protease inhibitors and other targeted therapies.
• Peptidomimetic Design: Used to introduce constrained, non-proteinogenic amino acid motifs into peptide backbones to enhance metabolic stability and binding affinity.
• Agrochemical Research: Serves as a precursor in the synthesis of novel chiral herbicides, fungicides, and plant growth regulators.
• Catalyst Ligand Synthesis: Employed in the preparation of sophisticated chiral ligands for asymmetric catalysis in fine chemical production.
• Biochemical Tool Development: Utilized in academic and industrial labs to create enzyme substrates, inhibitors, and probes for mechanistic studies.
• Material Science: Potential building block for advanced functional polymers and chiral stationary phases for chromatography.

Basic Information

Product Name	(S)-α-(2-Pyridinylmethyl)-Pro2Hcl
CAS No.	1217860-92-8
Molecular Formula	C12H17ClN2O2 • HCl
Molecular Weight	289.19 g/mol
Synonyms	(S)-2-(Pyridin-2-ylmethyl)pyrrolidine-2-carboxylic acid hydrochloride; L-2-(2-Pyridylmethyl)proline hydrochloride; (S)-α-(2-Pyridylmethyl)proline HCl; (2S)-2-[(Pyridin-2-yl)methyl]pyrrolidine-2-carboxylic acid hydrochloride; (S)-2-((Pyridin-2-yl)methyl)proline hydrochloride; (S)-Pyridylmethylproline HCl; (S)-PMP-OH•HCl
EINECS	Contact for details

Quality Control

Our (S)-α-(2-Pyridinylmethyl)-Pro2Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting research and development standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral excess, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.