Description

R-4-n-Boc-2-Cyanopiperidine is a high-purity, protected piperidine derivative that serves as a critical chiral building block in advanced organic synthesis. Its value lies in providing a versatile and stereochemically defined scaffold for constructing complex nitrogen-containing molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of active pharmaceutical ingredients (APIs) and novel bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel drug candidates, particularly in central nervous system (CNS) and antiviral research.
• Peptidomimetic Synthesis: Used to introduce constrained piperidine scaffolds into peptide backbones to enhance metabolic stability and bioavailability.
• Agrochemical Research: Serves as a building block for creating new pesticides and herbicides with specific chiral activity.
• Ligand and Catalyst Development: Employed in the synthesis of chiral ligands for asymmetric catalysis and organocatalysts.
• Chemical Biology Probes: Utilized to create molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis and Contract Manufacturing: A starting material for custom synthesis projects requiring high-purity, specialized intermediates.

Basic Information

Product Name	R-4-n-Boc-2-Cyanopiperidine
CAS No.	1217791-74-6
Molecular Formula	C12H20N2O2
Molecular Weight	224.30 g/mol
Synonyms	(R)-1-tert-Butyl 4-cyano-2-piperidinecarboxylate; (R)-1-Boc-4-cyano-2-piperidinecarboxylic acid; (R)-1-(tert-Butoxycarbonyl)-4-cyano-2-piperidinecarboxylic acid; (R)-4-Cyano-1-Boc-piperidine-2-carboxylic acid; (R)-N-Boc-4-cyano-2-piperidinecarboxylic acid; (R)-4-Cyano-2-piperidinecarboxylic acid tert-butyl ester; R-4-Cyano-1-Boc-piperidine-2-carboxylic acid; R-1-Boc-4-cyano-piperidine-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our R-4-n-Boc-2-Cyanopiperidine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and chiral integrity.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.