Description

Cyclobutaneacetic Acid, α-Amino-, Methyl Ester, (αs)- CAS NO 1217784-81-0 is a high-purity, non-natural amino acid derivative featuring a constrained cyclobutane ring system. This compound is a critical chiral building block for medicinal chemistry, enabling the synthesis of novel, conformationally restricted peptide analogs and small molecule drug candidates. It is primarily utilized by pharmaceutical R&D departments and fine chemical manufacturers focused on developing new therapeutic agents, particularly in areas requiring enhanced metabolic stability and receptor selectivity.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs).
• Peptidomimetics: Used to construct constrained peptide analogs for drug discovery programs targeting GPCRs, enzymes, and protein-protein interactions.
• Chemical Biology Probes: Incorporated into molecular probes to study enzyme mechanisms or protein function due to its unique steric and electronic properties.
• Asymmetric Synthesis: Acts as a chiral auxiliary or starting material in stereoselective synthesis routes for complex organic molecules.
• Agrochemical Research: Potential building block for the development of new crop protection agents with novel modes of action.
• Material Science: Investigated as a monomer or precursor for specialty polymers with tailored properties.

Basic Information

Product Name	Cyclobutaneacetic Acid, α-Amino-, Methyl Ester, (αs)-
CAS No.	1217784-81-0
Molecular Formula	C7H13NO2
Molecular Weight	143.18 g/mol
Synonyms	(αS)-α-Aminocyclobutanecetic acid methyl ester; Methyl (αS)-α-aminocyclobutanecetate; Methyl (1S)-1-amino-2-cyclobutylacetate; (S)-Methyl 2-amino-2-cyclobutylacetate; (S)-2-Amino-2-cyclobutylacetic acid methyl ester; L-Cyclobutylglycine methyl ester; (S)-Cyclobutylglycine methyl ester; CAS 1217784-81-0
EINECS	Contact for details

Quality Control

Our Cyclobutaneacetic Acid, α-Amino-, Methyl Ester, (αs)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) providing identity, purity, and impurity profile is supplied with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This material is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.